Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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The Brucella abortus general stress response system is required for chronic animal infection and exhibits noncanonical post-translational regulation

ABSTRACT: rpoE1 encodes an extracytoplasmic function (ECF) sigma factor to initiate the transcription of the genes responsible for general stress responses. This experiment is quantifying transcription in two Brucella strains: B. abortus 2308 wild type and rpoE1 in-frame deletion strains (gene bab1_1672).

ORGANISM(S): Brucella abortus

SUBMITTER: Hye-Sook Kim 

PROVIDER: E-MEXP-3722 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Brucella abortus general stress response system regulates chronic mammalian infection and is controlled by phosphorylation and proteolysis.

Kim Hye-Sook HS   Caswell Clayton C CC   Foreman Robert R   Roop R Martin RM   Crosson Sean S  

The Journal of biological chemistry 20130401 19

<h4>Background</h4>Virulence of pathogenic bacteria is often determined by their ability to adapt to stress.<h4>Results</h4>The Brucella abortus general stress response (GSR) system is required for chronic mammalian infection and is regulated by phosphorylation and proteolysis.<h4>Conclusion</h4>The B. abortus GSR signaling pathway has multiple layers of post-translational control and is a determinant of chronic infection.<h4>Significance</h4>This study provides new, molecular level insight into  ...[more]

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