Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

The Brucella abortus general stress response system is required for chronic animal infection and exhibits noncanonical post-translational regulation

ABSTRACT: rpoE1 encodes an extracytoplasmic function (ECF) sigma factor to initiate the transcription of the genes responsible for general stress responses. This experiment is quantifying transcription in two Brucella strains: B. abortus 2308 wild type and rpoE1 in-frame deletion strains (gene bab1_1672).

ORGANISM(S): Brucella abortus

SUBMITTER: Hye-Sook Kim 

PROVIDER: E-MEXP-3722 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

The Brucella abortus general stress response system regulates chronic mammalian infection and is controlled by phosphorylation and proteolysis.

Kim Hye-Sook HS   Caswell Clayton C CC   Foreman Robert R   Roop R Martin RM   Crosson Sean S  

The Journal of biological chemistry 20130401 19

<h4>Background</h4>Virulence of pathogenic bacteria is often determined by their ability to adapt to stress.<h4>Results</h4>The Brucella abortus general stress response (GSR) system is required for chronic mammalian infection and is regulated by phosphorylation and proteolysis.<h4>Conclusion</h4>The B. abortus GSR signaling pathway has multiple layers of post-translational control and is a determinant of chronic infection.<h4>Significance</h4>This study provides new, molecular level insight into  ...[more]

Similar Datasets

Transcriptomics Transcription profiling of B. abortus BvrS BvrR from B. abortus 2308
2010-04-22 | E-MEXP-2564 | biostudies-arrayexpress
Transcriptomics Expression Data from Brucella abortus strain 2308 and isogenic mavR mutant cells
2023-11-20 | GSE247672 | GEO
Transcriptomics Expression Data from Brucella abortus strain 2308 and isogenic vtlR mutant cells
2015-08-03 | GSE69564 | GEO
Transcriptomics Expression Data from Brucella abortus strain 2308 and isogenic vtlR mutant cells
2015-08-03 | E-GEOD-69564 | biostudies-arrayexpress
Transcriptomics Expression Data from Brucella abortus strain 2308 and isogenic mucR mutant cells
2012-12-01 | E-GEOD-40532 | biostudies-arrayexpress
Transcriptomics Expression Data from Brucella abortus strain 2308 and isogenic abcR1 abcR2 mutant cells
2012-06-14 | E-GEOD-38017 | biostudies-arrayexpress
Transcriptomics Expression Data from Brucella abortus strain 2308 and isogenic mucR mutant cells
2012-12-01 | GSE40532 | GEO
Transcriptomics Transcription profiling by array of changes produced in Brucella abortus by erythriyol
2013-05-03 | E-MTAB-1189 | biostudies-arrayexpress
Transcriptomics The Brucella abortus virulence regulator, LovhK, is a sensor kinase in the general stress response signaling pathway
2014-09-25 | GSE59513 | GEO
Transcriptomics Expression Data from Brucella abortus strain 2308 and isogenic abcR1 abcR2 mutant cells
2012-06-15 | GSE38017 | GEO