Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Leo Zeef
PROVIDER: E-MEXP-3746 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Reynolds John A JA Ray David W DW Zeef Leo A H LA O'Neill Terence T Bruce Ian N IN Alexander M Yvonne MY
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20140120 5
Cardiovascular disease (CVD) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus. The etiopathogenesis of premature CVD is not fully understood, but recently interferon-alpha (IFNα) has been implicated as a contributing factor. Since IFNα has been associated with both disease activity and endothelial dysfunction in lupus patients, we aimed to determine whether IFNα has direct effects on human aortic endothelial cell (HAoEC) function in vitro. We studied ...[more]