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Transcription profiling of minor salivary glands to identify distinct patterns of gene expression in patients with primary Sj¸gren?s syndrome (pSS), a frequent and prototype systemic autoimmune disease

ABSTRACT: Analysis of targets organs might help to get new insights into the pathogenesis of autoimmune diseases. We used global gene expression profiling of minor salivary glands to identify distinct patterns of gene expression in patients with primary Sjögrens syndrome (pSS), a frequent and prototype systemic autoimmune disease. Gene expression signature allowed to distinguish most patients with pSS from healthy controls

INSTRUMENT(S): ScanArray [PerkinElmer]

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: nicolas cagnard

PROVIDER: E-MEXP-419 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome.

Gottenberg Jacques-Eric JE Cagnard Nicolas N Lucchesi Carlo C Letourneur Franck F Mistou Sylvie S Lazure Thierry T Jacques Sebastien S Ba Nathalie N Ittah Marc M Lepajolec Christine C Labetoulle Marc M Ardizzone Marc M Sibilia Jean J Fournier Catherine C Chiocchia Gilles G Mariette Xavier X

Proceedings of the National Academy of Sciences of the United States of America 20060213 8

Gene expression analysis of target organs might help provide new insights into the pathogenesis of autoimmune diseases. We used global gene expression profiling of minor salivary glands to identify patterns of gene expression in patients with primary Sjögren's syndrome (pSS), a common and prototypic systemic autoimmune disease. Gene expression analysis allowed for differentiating most patients with pSS from controls. The expression of 23 genes in the IFN pathways, including two Toll-like recepto ...[more]

PMID: 16477017

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