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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of MIII celiac disease patients vs controls (M0) individuals

ABSTRACT: Comparison of MIII celiac disease patients to controls (M0) individuals.

ORGANISM(S): Homo sapiens

DISEASE(S): Marsh 3

SUBMITTER: Frank Holstege

PROVIDER: E-MEXP-42 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A microarray screen for novel candidate genes in coeliac disease pathogenesis.

Diosdado B B Wapenaar M C MC Franke L L Duran K J KJ Goerres M J MJ Hadithi M M Crusius J B A JB Meijer J W R JW Duggan D J DJ Mulder C J J CJ Holstege F C P FC Wijmenga C C

Gut 20040701 7

<h4>Background and aims</h4>The causative molecular pathways underlying the pathogenesis of coeliac disease are poorly understood. To unravel novel aspects of disease pathogenesis, we used microarrays to determine changes in gene expression of duodenal biopsies.<h4>Methods</h4>cDNA microarrays representing 19 200 genes were used to compare gene expression profiles of duodenal biopsies from 15 coeliac disease patients with villous atrophy (Marsh III) and seven control individuals with normal biop ...[more]

PMID: 15194641

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