Ontology highlight
ABSTRACT:
INSTRUMENT(S): ScanArray 6000 [Perkin Elmer]
ORGANISM(S): Escherichia coli
SUBMITTER: Georgi Muskhelishvili
PROVIDER: E-MEXP-462 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
BMC systems biology 20110315
<h4>Background</h4>The 3D structure of the chromosome of the model organism Escherichia coli is one key component of its gene regulatory machinery. This type of regulation mediated by topological transitions of the chromosomal DNA can be thought of as an analog control, complementing the digital control, i.e. the network of regulation mediated by dedicated transcription factors. It is known that alterations in the superhelical density of chromosomal DNA lead to a rich pattern of differential exp ...[more]