Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of E. coli LZ41 and LZ54 strains containing drug-resistant alleles of different topoisomerase genes treated with norfloxacin

ABSTRACT: Effect of supercoiling level on gene expression using LZ41 and LZ54 strains containing drug-resistant alleles of different topoisomerase genes. LZ41 strain treatment with norfloxacin strongly relaxes DNA, whereas in LZ54 strain the same treatment generates high negative supercoiling (Khodursky et al., 1995, PNAS 92:11801-5; Ziechedrich et al, 1997, Genes Dev. 11:2580-92).

INSTRUMENT(S): ScanArray 6000 [Perkin Elmer]

ORGANISM(S): Escherichia coli

SUBMITTER: Georgi Muskhelishvili 

PROVIDER: E-MEXP-463 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Analog regulation of metabolic demand.

Sonnenschein Nikolaus N   Geertz Marcel M   Muskhelishvili Georgi G   Hütt Marc-Thorsten MT  

BMC systems biology 20110315

<h4>Background</h4>The 3D structure of the chromosome of the model organism Escherichia coli is one key component of its gene regulatory machinery. This type of regulation mediated by topological transitions of the chromosomal DNA can be thought of as an analog control, complementing the digital control, i.e. the network of regulation mediated by dedicated transcription factors. It is known that alterations in the superhelical density of chromosomal DNA lead to a rich pattern of differential exp  ...[more]

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