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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of E. coli wild type and hns strains in rich dYT medium sampled in mid-exponential phase (ME), transition to stationary (TS) and late stationary phase (LS)

ABSTRACT: Growth curves wt and hns strains in rich dYT medium. Sample in Mid-exponential phase (ME), Transition to Stationary (TS) and Late Stationary phase (LS).

INSTRUMENT(S): ScanArray 6000 [Perkin Elmer]

ORGANISM(S): Escherichia coli

SUBMITTER: Georgi Muskhelishvili

PROVIDER: E-MEXP-464 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Homeostatic regulation of supercoiling sensitivity coordinates transcription of the bacterial genome.

Blot Nicolas N Mavathur Ramesh R Geertz Marcel M Travers Andrew A Muskhelishvili Georgi G

EMBO reports 20060616 7

Regulation of cellular growth implies spatiotemporally coordinated programmes of gene transcription. A central question, therefore, is how global transcription is coordinated in the genome. The growth of the unicellular organism Escherichia coli is associated with changes in both the global superhelicity modulated by cellular topoisomerase activity and the relative proportions of the abundant DNA-architectural chromatin proteins. Using a DNA-microarray-based approach that combines mutations in t ...[more]

PMID: 16799466

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