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Transcription profiling of D34+ BCR-ABL+ cells of CML patients in chronic phase or blast crisis to identify differentially expressed stage-specific genes

ABSTRACT: Profiling CD34+ BCR-ABL+ cells of CML patients in chronic phase or blast crisis to identify differentially expressed stage-specific genes.

ORGANISM(S): Homo sapiens

SUBMITTER: Andreas Hochhaus

PROVIDER: E-MEXP-480 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis.

Zheng C C Li L L Haak M M Brors B B Frank O O Giehl M M Fabarius A A Schatz M M Weisser A A Lorentz C C Gretz N N Hehlmann R R Hochhaus A A Seifarth W W

Leukemia 20060601 6

Despite recent success in the treatment of early-stage disease, blastic phase (BP) of chronic myeloid leukemia (CML) that is characterized by rapid expansion of therapy-refractory and differentiation-arrested blasts, remains a therapeutic challenge. The development of resistance upon continuous administration of imatinib mesylate is associated with poor prognosis pointing to the need for alternative therapeutic strategies and a better understanding of the molecular mechanisms underlying disease ...[more]

PMID: 16617318

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