Transcription profiling of hippocampal neuronal cell line HT-22 after 7 days of 3mM Lithium treatment
Ontology highlight
ABSTRACT:
INSTRUMENT(S): GenePix 4000B [Axon Instruments]
ORGANISM(S): Mus musculus
SUBMITTER: Eugenia Yazlovitskaya
PROVIDER: E-MEXP-521 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation.
Yazlovitskaya Eugenia M EM Edwards Eric E Thotala Dinesh D Fu Allie A Osusky Kate L KL Whetsell William O WO Boone Braden B Shinohara Eric T ET Hallahan Dennis E DE
Cancer research 20061201 23
Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation-induced apoptosis and decreased neurogenesis in the subgranular zone of the hippocampus. We show that lithium treatment protects irradiated hippocampal neurons from apoptosis and improves cognitive performance of irradiated mice. The molecular mechanism of this effect is mediated through multiple pathways, inclu ...[more]
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