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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat ileum mucosa and Peyers patches in the small intestine at different time points following Salmonella infection

ABSTRACT: Time dependent effect of Salmonella infection on host gene expression in vivo in the ileum mucosa and Peyers patches.

INSTRUMENT(S): ScanArray Express HT [PerkinElmer]

ORGANISM(S): Rattus norvegicus

SUBMITTER: Wendy Rodenburg

PROVIDER: E-MEXP-636 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression response of the rat small intestine following oral Salmonella infection.

Rodenburg Wendy W Bovee-Oudenhoven Ingeborg M J IM Kramer Evelien E van der Meer Roelof R Keijer Jaap J

Physiological genomics 20070320 2

Data on the molecular response of the intestine to the food-borne pathogen Salmonella are derived from in vitro studies, whereas in vivo data are lacking. We performed an oral S. enteritidis infection study in Wistar rats to obtain insight in the in vivo response in time. Expression profiles of ileal mucosa (IM) and Peyer's patches (PP) were generated using DNA microarrays at days 1, 3, and 6 postinfection. An overview of Salmonella-regulated processes was obtained and confirmed by quantitative ...[more]

PMID: 17374845

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