Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of fission yeast cell cycle, HU block and release

ABSTRACT: Cell cycle regulation in fission yeast using replication arrest by hydroxyurea

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Alvis Brazma 

PROVIDER: E-MEXP-64 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cell-cycle control of transcription seems to be universal, but little is known about its global conservation and biological significance. We report on the genome-wide transcriptional program of the Schizosaccharomyces pombe cell cycle, identifying 407 periodically expressed genes of which 136 show high-amplitude changes. These genes cluster in four major waves of expression. The forkhead protein Sep1p regulates mitotic genes in the first cluster, including Ace2p, which activates transcription in  ...[more]

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