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Transcription profiling of human normal neuroblasts vs. malignant neuroblastomas (low- and high-stage)

ABSTRACT: Comparison of normal neuroblasts with malignant neuroblastomas (low- and high-stage)

ORGANISM(S): Homo sapiens

DISEASE(S): low-stage neuroblastoma

SUBMITTER: Katleen De Preter

PROVIDER: E-MEXP-669 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes.

De Preter Katleen K Vandesompele Jo J Heimann Pierre P Yigit Nurten N Beckman Siv S Schramm Alexander A Eggert Angelika A Stallings Raymond L RL Benoit Yves Y Renard Marleen M De Paepe Anne A Laureys Geneviève G Påhlman Sven S Speleman Frank F

Genome biology 20060101 9

<h4>Background</h4>Neuroblastoma tumor cells are assumed to originate from primitive neuroblasts giving rise to the sympathetic nervous system. Because these precursor cells are not detectable in postnatal life, their transcription profile has remained inaccessible for comparative data mining strategies in neuroblastoma. This study provides the first genome-wide mRNA expression profile of these human fetal sympathetic neuroblasts. To this purpose, small islets of normal neuroblasts were isolated ...[more]

PMID: 16989664

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