Ontology highlight
ABSTRACT:
INSTRUMENT(S): Axon GenePix4000B
ORGANISM(S): Homo sapiens
SUBMITTER: Claes Wadelius
PROVIDER: E-MEXP-693 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Human molecular genetics 20051012 22
We present a detailed in vivo characterization of hepatocyte transcriptional regulation in HepG2 cells, using chromatin immunoprecipitation and detection on PCR fragment-based genomic tiling path arrays covering the encyclopedia of DNA element (ENCODE) regions. Our data suggest that HNF-4alpha and HNF-3beta, which were commonly bound to distal regulatory elements, may cooperate in the regulation of a large fraction of the liver transcriptome and that both HNF-4alpha and USF1 may promote H3 acety ...[more]