Ontology highlight
ABSTRACT:
INSTRUMENT(S): NextSeq 500
ORGANISM(S): Mus musculus
SUBMITTER: Menno Oudhoff
PROVIDER: E-MTAB-8710 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zwiggelaar Rosalie T RT Lindholm Håvard T HT Fosslie Madeleine M Terndrup Pedersen Marianne M Ohta Yuki Y Díez-Sánchez Alberto A Martín-Alonso Mara M Ostrop Jenny J Matano Mami M Parmar Naveen N Kvaløy Emilie E Spanjers Roos R RR Nazmi Kamran K Rye Morten M Drabløs Finn F Arrowsmith Cheryl C Arne Dahl John J Jensen Kim B KB Sato Toshiro T Oudhoff Menno J MJ
Science advances 20200911 37
Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that lysine-specific demethylase 1A (<i>Kdm1a/Lsd1</i>) is absolutely required for Paneth cell differentiation. <i>Lsd1</i>-deficient crypts, devoid of Panet ...[more]