Dataset Information
Transcription profiling of camptothecin treatment time series performed on human U87 glioma cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): DNA Microarray Scanner BA [Agilent Technologies]
ORGANISM(S): Homo sapiens
SUBMITTER: Elena Morandi
PROVIDER: E-MEXP-741 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression time-series analysis of camptothecin effects in U87-MG and DBTRG-05 glioblastoma cell lines.
Molecular cancer 20080811
<h4>Background</h4>The clinical efficacy of camptothecin (CPT), a drug specifically targeting topoisomerase I (TopoI), is under evaluation for the treatment of malignant gliomas. Due to the high unresponsiveness of these tumours to chemotherapy, it would be very important to study the signalling network that drives camptothecin outcome in this type of cancer cells. To address this issue, we had previously compared the expression profile of human U87-MG glioblastoma cells with that of a CPT-resis ...[more]
