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Transcription profiling of camptothecin treatment time series performed on human DBTRG-05MG glioma cells

ABSTRACT: Time-series analysis of camptothecin effects on DBTRG-05MG glioma cell line

INSTRUMENT(S): DNA Microarray Scanner BA [Agilent Technologies]

ORGANISM(S): Homo sapiens

SUBMITTER: Elena Morandi 

PROVIDER: E-MEXP-751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chemotherapy, as generally available, is of a limited value in curing malignant brain tumors (gliomas), which often develop resistance to drugs, becoming completely unresponsive to any standard therapeutic approach. Camptothecins, a family of topoisomerase I inhibitor drugs, represent a new promising treatment strategy and are currently under evaluation for testing the clinical efficacy. We selected a CPT-resistant sub-line (U87CPT-R) from U87-MG grade III-IV astrocytoma cells, and compared the  ...[more]

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