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Transcription profiling of human hippocampi from epilepsy patients with and without hippocampal sclerosis and autopsy controls

ABSTRACT: Genome wide gene expression was compared between nonHS, HS temporal lobe epilepsy patients (TLE) and autopsy control hippocampi in a 3-way analysis. In many TLE patients the hippocampus is subject to massive neuronal damage, gliosis and hippocampal sclerosis (HS), while in others there is no apparent hippocampal damage (nonHS). This three way analysis enabled us to differentiate between pathology and epilepsy related processes.

INSTRUMENT(S): G2565AA DNA microarray scanner [Agilent]

ORGANISM(S): Homo sapiens

DISEASE(S): temporal lobe epilepsy

SUBMITTER: Marian Groot Koerkamp

PROVIDER: E-MEXP-744 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Possible role of the innate immunity in temporal lobe epilepsy.

van Gassen Koen L I KL de Wit Marina M Koerkamp Marian J A Groot MJ Rensen Marije G A MG van Rijen Peter C PC Holstege Frank C P FC Lindhout Dick D de Graan Pierre N E PN

Epilepsia 20071211 6

<h4>Purpose</h4>Temporal lobe epilepsy (TLE) is a multifactorial disease often involving the hippocampus. So far the etiology of the disease has remained elusive. In some pharmacoresistant TLE patients the hippocampus is surgically resected as treatment. To investigate the involvement of the immune system in human TLE, we performed large-scale gene expression profiling on this human hippocampal tissue.<h4>Methods</h4>Microarray analysis was performed on hippocampal specimen from TLE patients wit ...[more]

PMID: 18076643

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