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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse fibroblast-like cells infected with mouse hepatitis virus

ABSTRACT: Effect of mouse hepatitis virus strain A59 replication on gene expression and mRNA stability in LR cells

INSTRUMENT(S): G2565AA DNA microarray scanner [Agilent]

ORGANISM(S): Mus musculus

SUBMITTER: Matthijs Raaben

PROVIDER: E-MEXP-895 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies.

Raaben Matthijs M Groot Koerkamp Marian J A MJ Rottier Peter J M PJ de Haan Cornelis A M CA

Cellular microbiology 20070508 9

Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome-wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)-infected cells. At the time of MHV-induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation-related factors, was observed. This downregulation, which is reminiscent of a cellular stress respons ...[more]

PMID: 17490409

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