Transcription profiling of mouse splenic B cells expressing a dominant-negative p300 allele which lacks histone acetyltransferase activity
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ABSTRACT: The p300 protein is one of more than 15 known mammalian HATs. We have used mice that carry a mutant allele of the p300 gene, which encodes a full-length protein that, however, lacks detectable acetyltransferase (AT)-activity and that acts in a dominant-negative manner. In addition, the allele is conditional, so that it can be expressed in a tissue-specific manner with the help of mice that express Cre-recombinase. Expression of the mutant allele specifically in B-cells, using CD19-cre mice, results in premature death with full penetrance from an autoimmune disease that closely mimics systemic lupus erythematosus (SLE) in its pathological manifestations.
INSTRUMENT(S): ScanArray Express HT [PerkinElmer]
ORGANISM(S): Mus musculus
DISEASE(S): normal
SUBMITTER: Werner Lutz
PROVIDER: E-MEXP-747 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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