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Transcription profiling of thymocyte differentiation in knockout mouse models

ABSTRACT: Microarray experiment with whole thymi from genetically enginereed mice, with purified thymocyte samples and with cell lines.

ORGANISM(S): Mus musculus

DISEASE(S): autoimmune disorder

SUBMITTER: Catherine Nguyen

PROVIDER: E-MEXP-96 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A general survey of thymocyte differentiation by transcriptional analysis of knockout mouse models.

Puthier Denis D Joly Florence F Irla Magali M Saade Murielle M Victorero Geneviève G Loriod Béatrice B Nguyen Catherine C

Journal of immunology (Baltimore, Md. : 1950) 20041101 10

The thymus is the primary site of T cell lymphopoiesis. To undergo proper differentiation, developing T cells follow a well-ordered genetic program that strictly depends on the heterogeneous and highly specialized thymic microenvironment. In this study, we used microarray technology to extensively describe transcriptional events regulating alphabeta T cell fate. To get an integrated view of these processes, both whole thymi from genetically engineered mice together with purified thymocytes were ...[more]

PMID: 15528347

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