Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

80 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of human lung adenocarcinoma A549 cells treated with vehicle (DMSO) or Etoposide (ETOP, 10 uM ), Benzo(a)pyrene Cryptolepineand 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine for 6 h, 16 h, 24 h, 48 h and 72 h

ABSTRACT: Title: Prediction of cell cycle behaviour in response to DNA damage agents via transcriptomic approach
Description: Human lung adenocarcinoma A549 cells were treated with vehicle (DMSO) or Etoposide (ETOP, 10 M-BM-5M ), Benzo(a)pyrene (BaP, 25 M-BM-5M ), Cryptolepine ( CLP, 2.5 M-BM-5M) and 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP, 50 M-BM-5M) for 6 h, 16 h, 24 h, 48 h and 72 h.

ORGANISM(S): Homo sapiens

DISEASE(S): carcinoma

SUBMITTER: unknown unknown

PROVIDER: E-MIMR-102 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of mouse adipocytes to determine the role of RIP140 in adipocyte differentiation

Project description:Title: Gene Expression analysis of the role of RIP140 in adipocyte differentiation Description: RIPKO cells are mouse embryo fibroblasts (MEF) that were derived from RIP140-knockout mice and have been established as a RIP140 null cell line, while RIPKO-L7 and RIPKO-L16 are RIPKO cells for which the expression of RIP140 has been reintroduced using a lentiviral expression system. Using an established standard cocktail of hormones that includes IBMX, insulin, dexamethasone and a PPAR gamma agonist the cells were differentiated into adipocytes and RNA isolated at day 0 and day 10 after the addition of the cocktail.

2013-01-30 | E-MIMR-42 | biostudies-arrayexpress

Transcription profiling of human indolent and aggressive forms of Chronic Myeloid Leukaemia (CML)

Project description:Title: Gene expression analysis of indolent and aggressive forms of Chronic Myeloid Leukaemia (CML). Description: Chronic Myeloid Leukaemia presents in chronic phase (CP) and terminates in 'blast crisis'. Despite a common abnormality, the duration of CP is variable. The aim is to compare the gene expression profiles of the indolent and aggressive forms of CML. All samples were taken within 3 months of first diagnosis. Indolent patients were defined by chronic phase CML, duration minimum 7 years. Aggressive patients were defined by chronic phase, duration maximum 3 years.

2013-01-30 | E-MIMR-17 | biostudies-arrayexpress

Transcription profiling of 5 human parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubicin

Project description:Title: Analysis of gene expression changes involved in the development of acquired drug resistance. Description: In vitro model of drug resistance consisting of 5 parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubicin. Model used to identify genes involved in the drug resistant phenotype.

2006-09-01 | E-MIMR-11 | biostudies-arrayexpress

Transcription profiling of ovarian gene expression in RIP140 wild type, heterozygous and knock out mice

Project description:Title: Comparison of ovarian gene expression in RIP140 wild type, heterozygous and knock out mice. Description: RIP140 null mice fail to ovulate. This experiment was designed to determine the gene expression profile of these animals compared to wild type and heterozygous animals following hormone treatments that induce the biological changes required for ovulation to occur.

2005-05-11 | E-MIMR-43 | biostudies-arrayexpress

Transcription profiling of BXSB mice to study lupus erythematosus

Project description:Genetic basis of systemic lupus erythematosus in BXSB mice.

2013-01-30 | E-MIMR-7 | biostudies-arrayexpress

Transcription profiling of PPAR alpha function in fibrate fed animals during light and dark cycles

Project description:Title: Study of PPAR alpha function in fibrate fed animals during light and dark cycles. Description: Study of PPAR alpha function in fibrate fed animals during light and dark cycles.

2005-05-10 | E-MIMR-2 | biostudies-arrayexpress

Transcription profiling of human heart tissue: hibernating versus normal myocardium

Project description:Title: Gene expression profiling of human heart samples: a comparison between normal and hibernating myocardium. Description: The aim of this project is to investigate the changes in global gene expression in hibernating,(preserved wall thickness, impaired contractility at rest, recruitable with low dose dobutamine and 50% transmural hyperenhancement with gadolinium) and normal myocardium, (preserved myocardial wall thickness, normal contractility, no significant improvement in functional recruitability with dobutamine and no cardiac fibrosis seen).

2006-12-31 | E-MIMR-27 | biostudies-arrayexpress

Transcription profiling of phenylepherine response in rat neonatal ventricular myocytes

Project description:Title: Regulation of gene expression through mitogen-activated protein kinase cascades in cardiac myocytes. Description: We aim to identify the changes in gene expression induced in rat neonatal ventricular myocytes, a well established cell culture model, by phenylepherine, a known hypertrophic agonist, and to determine which of the changes are mediated through the ERK cascade. In addition, we intend to extend the previous studies (EXP_TKAC_0102_01 and EXP_TKAC_1103_02) on endothelin-1 induced hypertrophy and the oxidative stress induced by H2O2 by using additional concentrations and timepoints.

2006-10-01 | E-MIMR-37 | biostudies-arrayexpress

Transcription profiling of rat neonatal ventricular myocytes

Project description:Title: Regulation of gene expression through mitogen-activated protein kinase cascades in cardiac myocytes. Description: The aim of this study is to identify the changes in gene expression induced in rat neonatal ventricular myocytes, a well-established cell culture model, by endothelin-1, a known hypertrophic agonist, and to determine which of the changes are mediated through the ERK cascade. This continues TKAC^Ys previous study of the effects of oxidative stress, which induces cardiac myocyte apoptosis.

2006-10-01 | E-MIMR-3 | biostudies-arrayexpress

Transcription profiling of H2O2 treated rat cardiac myocytes

Project description:Title: Changes in gene expression affected by H2O2 in cardiac myocytes. Description: We aim to identify the changes in gene expression in response to oxidative stress in rat neonatal ventricular myocytes. Oxidative stress will be induced by dosing neonatal ventricular myocyte cultures with 0.2, 0.1 and 0.04mM hydrogen peroxide at 2, 4 and 8 hr time points using unstimulated myocytes as control.

2011-11-08 | E-MIMR-12 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data