Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of mouse colon to investigate how influenza infection leads to intestinal disorders


ABSTRACT: To study the impact of influenza infection on gene expression changes in the colon, mice were intra-nasally infected with 30 plaque forming units of the mouse-adapted H3N2 IAV strain Scotland/20/1974. PBS-treated mice served as controls. The colons were collected 7 days post-infection. The 4 samples presented here are \\"pair feed\\" controls of the samples presented in E-MTAB-6707. To provide the pair-fed group with only as much food daily as is consumed by IAV-infected mice, we restricted the food access during the last three days for 15% (day 4), 35% (day 5) and 85% (day 6), respectively (sacrifice at day 7). Mice were anesthetized at day 0. Food was supplied twice a day to pair-fed animals and water was available at all times. The ad libitum (normally nourished) group mice were allowed unrestricted access to food and water. At the sacrifice, paired-fed mice lost ~15% of body mass.

ORGANISM(S): Mus musculus

SUBMITTER: Ronan Le Goffic 

PROVIDER: E-MTAB-10036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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