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Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic response to ex vivo IL33 stimulation of blood eosinophils from mepolizumab- or omalizumab-treated patients

ABSTRACT: Coding RNA expression of blood eosinophils from mepolizumab- or omalizumab-treated patients stimulated ex vivo with IL-33 for 6 hours and of directly processed non-stimulated blood eosinophils from the same samples (paired design)

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Christophe Desmet

PROVIDER: E-MTAB-10189 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Anti-IL5 mepolizumab minimally influences residual blood eosinophils in severe asthma.

Van Hulst Glenn G Jorssen Joseph J Jacobs Nathalie N Henket Monique M Louis Renaud R Schleich Florence F Bureau Fabrice F Desmet Christophe J CJ

The European respiratory journal 20220317 3

Neutralising antibodies against the cytokine interleukin (IL)5 have become widely used for the control of severe eosinophilic asthma. Remarkably, patients receiving neutralising anti-IL5 biological therapies retain a very stable population of residual blood eosinophils. Whether these residual eosinophils are endowed with particular biological activity has not yet been studied, but is of importance in predicting potential long-term effects of IL5 neutralisation in patients. To tackle the effect o ...[more]

PMID: 34475229

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Expression data of hiPSC-derived anterior foregut endoderm cells (AFECs), ventral anterior foregut cells (VAFECs), EpCAM+CPM+ and EpCAM+CPM- cells and CPM+ cells sorted from VAFECs

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