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Comparison of coding RNA expression of blood eosinophils from mepolizumab- or omalizumab-treated severe asthmatic patients and from healthy controls

ABSTRACT: RNA-seq comparison of coding RNA expression in blood eosinophils from patients with severe allergic eosinophilic asthma treated with mepolizumab with those of healthy controls and matched severe asthmatic patients receiving omalizumab.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Christophe Desmet

PROVIDER: E-MTAB-10190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Anti-IL5 mepolizumab minimally influences residual blood eosinophils in severe asthma.

Van Hulst Glenn G Jorssen Joseph J Jacobs Nathalie N Henket Monique M Louis Renaud R Schleich Florence F Bureau Fabrice F Desmet Christophe J CJ

The European respiratory journal 20220317 3

Neutralising antibodies against the cytokine interleukin (IL)5 have become widely used for the control of severe eosinophilic asthma. Remarkably, patients receiving neutralising anti-IL5 biological therapies retain a very stable population of residual blood eosinophils. Whether these residual eosinophils are endowed with particular biological activity has not yet been studied, but is of importance in predicting potential long-term effects of IL5 neutralisation in patients. To tackle the effect o ...[more]

PMID: 34475229

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