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Transcription profiling by array of adult Drosophila melanogaster gut and fat body in S1106>dfoxo females after 5 days of induction of transgene expression by RU486 feeding.

ABSTRACT: Transcription profiling by array of adult abdominal/thorasic fat body or midgut in S1106>dfoxo females after 5 days of induction of transgene expression by RU486 feeding.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Nazif Alic

PROVIDER: E-MTAB-1020 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster.

Alic Nazif N Giannakou Maria E ME Papatheodorou Irene I Hoddinott Matthew P MP Andrews T Daniel TD Bolukbasi Ekin E Partridge Linda L

PLoS genetics 20140918 9

Forkhead box O (FoxO) transcription factors (TFs) are key drivers of complex transcriptional programmes that determine animal lifespan. FoxOs regulate a number of other TFs, but how these TFs in turn might mediate the anti-ageing programmes orchestrated by FoxOs in vivo is unclear. Here, we identify an E-twenty six (ETS)-family transcriptional repressor, Anterior open (Aop), as regulated by the single Drosophila melanogaster FoxO (dFOXO) in the adult gut. AOP, the functional orthologue of the hu ...[more]

PMID: 25232726

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