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Transcriptional analysis of dInR and dfoxo epistasis in Drosophila melanogaster

ABSTRACT: Transcriptional analysis of dInR and dfoxo epistasis in Drosophila melanogaster. The experiment was performed to examine which parts of the transcriptional response to a reduction in insulin signalling in an adult female fly depend on the presence of the dfoxo transcription factor. Whole fly transcriptome was determined with flies over-expressing a dominant negative form of the insulin receptor, or the wild-type fly, in presence or absence of dfoxo.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Nazif Alic 

PROVIDER: E-TABM-757 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling.

Alic Nazif N   Andrews T Daniel TD   Giannakou Maria E ME   Papatheodorou Irene I   Slack Cathy C   Hoddinott Matthew P MP   Cochemé Helena M HM   Schuster Eugene F EF   Thornton Janet M JM   Partridge Linda L  

Molecular systems biology 20110621

FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult female Drosophila. dFOXO is directly required for transcription of several IIS components and interacting pathways, such as TOR, in the wild-type fly. The genomic locations occupied by dFOXO in adults are different from those observed in larvae or cultured cells  ...[more]

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