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ChIP-chip by array of yeast strains BY and RM after TSA treatment and recovery using anti-H3K14ac polyclonal antibody to investigate the stability of chromatin acetylation epi-polymorphisms

ABSTRACT: Strains BY and RM were cultivated with high concentrations of Trichostatin-A (TSA) and then let recover for >20 generations before re-profiling H3K14ac by ChIP as in Nagarajan et al. 2010 PLoS Genetics

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Gael Yvert

PROVIDER: E-MTAB-1025 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms.

Abraham Anne-Laure AL Nagarajan Muniyandi M Veyrieras Jean-Baptiste JB Bottin Hélène H Steinmetz Lars M LM Yvert Gaël G

PLoS genetics 20120920 9

Natural populations are known to differ not only in DNA but also in their chromatin-associated epigenetic marks. When such inter-individual epigenomic differences (or "epi-polymorphisms") are observed, their stability is usually not known: they may or may not be reprogrammed over time or upon environmental changes. In addition, their origin may be purely epigenetic, or they may result from regulatory variation encoded in the DNA. Studying epi-polymorphisms requires, therefore, an assessment of t ...[more]

PMID: 23028365

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