Dataset Information
The roles of 3’-exoribonucleases and the exosome in trypanosome mRNA degradation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome analyzer IIx
ORGANISM(S): Trypanosoma brucei brucei
SUBMITTER: Christine Clayton
PROVIDER: E-MTAB-10260 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The roles of 3'-exoribonucleases and the exosome in trypanosome mRNA degradation.
RNA (New York, N.Y.) 20130522 7
The degradation of eukaryotic mRNAs can be initiated by deadenylation, decapping, or endonuclease cleavage. This is followed by 5'-3' degradation by homologs of Xrn1, and/or 3'-5' degradation by the exosome. We previously reported that, in African trypanosome Trypanosoma brucei, most mRNAs are deadenylated prior to degradation, and that depletion of the major 5'-3' exoribonuclease XRNA preferentially stabilizes unstable mRNAs. We now show that depletion of either CAF1 or CNOT10, two components o ...[more]
