Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Homo sapiens
SUBMITTER: Sue Kimber
PROVIDER: E-MTAB-10279 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Woods Steven S Humphreys Paul A PA Bates Nicola N Richardson Sophie Alice SA Kuba Shweta Yogesh SY Brooks Imogen R IR Cain Stuart A SA Kimber Susan J SJ
Cells 20210324 4
The growth factor TGFβ and the mechanosensitive calcium-permeable cation channel TRPV4 are both important for the development and maintenance of many tissues. Although TRPV4 and TGFβ both affect core cellular functions, how their signals are integrated is unknown. Here we show that pharmacological activation of TRPV4 significantly increased the canonical response to TGFβ stimulation in chondrocytes. Critically, this increase was only observed when TRPV4 was activated after, but not before TGFβ s ...[more]