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Genome-wide identification and DNA methylation of human full-length LINE-1 (L1) retrotransposons in a panel of normal and cancer cell lines.

ABSTRACT: We used bs-ATLAS-seq to comprehensively map the genomic location and assess the DNA methylation status of human full-length LINE-1 elements (L1). The approach is focused on the youngest family (L1HS), but it also catches a significant fraction of L1PA2 to L1PA8 elements. This was performed in a panel of 12 human primary or transformed cell lines (BJ, IMR90, MRC5, H1, K562, HCT116, HeLa S3, HepG2, MCF7, HEK-293, HEK-293T, 2102Ep).

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Gael Cristofari

PROVIDER: E-MTAB-10895 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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