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Single cell sequencing of the proliferative endometrium

ABSTRACT: Endometrial biopsies were collected on menstrual cycle day 7 from healthy fertile women age 24-42. Biopsies were processed to a single cell suspension and submitted for single cell sequencing on the 10x platform.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Nageswara Rao Boggavarapu

PROVIDER: E-MTAB-10947 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Stromal Heterogeneity in the Human Proliferative Endometrium-A Single-Cell RNA Sequencing Study.

Queckbörner Suzanna S von Grothusen Carolina C Boggavarapu Nageswara Rao NR Francis Roy Mathew RM Davies Lindsay C LC Gemzell-Danielsson Kristina K

Journal of personalized medicine 20210522 6

The endometrium undergoes regular regeneration and stromal proliferation as part of the normal menstrual cycle. To better understand cellular interactions driving the mechanisms in endometrial regeneration we employed single-cell RNA sequencing. Endometrial biopsies were obtained during the proliferative phase of the menstrual cycle from healthy fertile women and processed to single-cell suspensions which were submitted for sequencing. In addition to known endometrial cell types, bioinformatic a ...[more]

PMID: 34067358

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