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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Single cell RNA sequencing of healthy and trisomy 21 (Down's syndrome) foetal liver and foetal bone marrow

ABSTRACT: Here, we performed single cell RNA sequencing (scRNA-seq) of human fetal liver and bone marrow tissue samples from 15 trisomy 21 (Ts21) and 3 healthy foetuses (median age 14 post-conception weeks). The data set is composed of approximately 1.1 million cells from three different populations: CD235- (niche and haematopoietic cells depleted of erythrocytes), CD34+/Lin- (haematopoietic progenitors), and CD45+ (all haematopoietic cells).

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Marco De Zuani

PROVIDER: E-MTAB-13067 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Multiome scRNA- and scATAC-seq of healthy and trisomy 21 (Down's syndrome) foetal liver

Project description:Here, we performed multiome sequencing (snRNA-seq + snATAC-seq) of human fetal liver samples from 3 trisomy 21 (Ts21) and 3 healthy foetuses (median age 14 post-conception weeks). The data set is composed of approximately 60,000 CD45+ foetal liver cells.

2024-07-17 | E-MTAB-13070 | biostudies-arrayexpress

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Haematopoietic stem and progenitor cells are present in healthy gingiva tissue

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Single-cell RNA-seq (10x Chromium) of FACS-sorted drl:H2B-Dendra2, etv2:Kaede, fli1:DsRed, and tp1:eGFP transgenic zebrafish embryos

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