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Pustular psoriasis: molecular pathways and effects of spesolimab in generalized pustular psoriasis

ABSTRACT: pre- and post spesolimab treatment gene expression analysis of blood as well as skin biopsy samples.

INSTRUMENT(S): Illumina HiSeq 3000

ORGANISM(S): Homo sapiens

SUBMITTER: Patrick Baum

PROVIDER: E-MTAB-11144 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pustular psoriasis: Molecular pathways and effects of spesolimab in generalized pustular psoriasis.

Baum Patrick P Visvanathan Sudha S Garcet Sandra S Roy Janine J Schmid Ramona R Bossert Sebastian S Lang Benjamin B Bachelez Hervé H Bissonnette Robert R Thoma Christian C Krueger James G JG

The Journal of allergy and clinical immunology 20211020 4

<h4>Background</h4>The IL-36 pathway plays a key role in the pathogenesis of generalized pustular psoriasis (GPP). In a proof-of-concept clinical trial, treatment with spesolimab, an anti-IL-36 receptor antibody, resulted in rapid skin and pustular clearance in patients presenting with GPP flares.<h4>Objective</h4>We sought to compare the molecular profiles of lesional and nonlesional skin from patients with GPP or palmoplantar pustulosis (PPP) with skin from healthy volunteers, and to investiga ...[more]

PMID: 34678325

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