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Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional remodeling of lymphatic endothelial cells from tumor-draining lymph nodes in melanoma

ABSTRACT: We investigated transcriptional changes in lymphatic endothelial cells lining tumor-draining lymph nodes in melanoma using single-cell RNA sequencing.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Lothar Dieterich

PROVIDER: E-MTAB-11524 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Melanoma-derived extracellular vesicles mediate lymphatic remodeling and impair tumor immunity in draining lymph nodes

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Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes

Project description:Using single-cell RNA sequencing, we provide a comprehensive map of lymph node resident lymphatic endothelial cells, identifying subpopulations, new markers and functions.

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2021-06-02 | E-MTAB-10435 | biostudies-arrayexpress

Melanoma-derived extracellular vesicles mediate lymphatic remodeling and impair tumor immunity in draining lymph nodes

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Unraveling Transcriptomic Heterogeneity in the Human Dermal Blood Vascular Endothelium at Single-Cell Resolution

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Transcription profiling of human lymphatic endothelial cells response to Kaposi-sarcoma herpesvirus

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2006-10-23 | E-MEXP-561 | biostudies-arrayexpress

Transcription profiling of lymphatic endothelial cells infected with Kaposi's sacoma associated herpes virus

Project description:This SuperSeries is composed of the following subset Series: GSE16353: The profile of cellular and KSHV microRNAs in AIDS_KS biopsies (and normal skin control biopsies) GSE16354: Infection of Lymphatic and Blood Vessel Endothelial Cells (LEC and BEC) with KSHV GSE16355: Lymphatic endothelial cells (LEC) transfected with the KSHV microRNA cluster GSE16356: Lymphatic endothelial cells (LEC) treated with a MAF-targeted siRNA Refer to individual Series

2009-09-30 | E-GEOD-16357 | biostudies-arrayexpress

The profile of cellular and KSHV microRNAs in KSHV infected lymphatic endothelial cells (6 and 72 hours post infection)

Project description:Kaposi sarcoma is the most common cancer in AIDS patients and is typified by red skin lesions. The disease is caused by the KSHV virus (HHV8) and is recognizable by its distinctive red skin lesions. The lesions are KSHV infected spindle cells, most commonly the lymphatic endothelial and blood vessel endothelial cells (LEC and BEC), plus surrounding stroma. The effects of KSHV infection of LECs were assayed using Affymetrix hgu133plus2 chips at 6 and 72 hours post infection. There were n=4 each of lymphatic endothelial cells (LEC) following 6 hours of culture, LEC following 6 hours post KSHV infection, LEC following 72 hours of culture, and LEC following 72 hours post KSHV infection.

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RNAi knock down of MAFin human lymphatic endothelial cells

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2009-10-10 | E-GEOD-16356 | biostudies-arrayexpress

Lymphatic-draining nanoparticles deliver Bay K8644 payload to lymphatic vessels and enhance their pumping function.

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| S-EPMC9956116 | biostudies-literature

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