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Transcription profiling of human lymphatic endothelial cells response to Kaposi-sarcoma herpesvirus

ABSTRACT: Assessment of the effect of Kaposi-sarcoma herpesvirus upon the transcriptome of lymphatic endothelial cells and its contribution to the transcriptome of Kaposi sarcoma.

ORGANISM(S): Homo sapiens

DISEASE(S): Kaposi's sarcoma

SUBMITTER: Stephen Henderson

PROVIDER: E-MEXP-561 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells.

Lagos Dimitrios D Trotter Matthew W B MW Vart Richard J RJ Wang Hsei-Wei HW Matthews Nick C NC Hansen Amy A Flore Ornella O Gotch Frances F Boshoff Chris C

Blood 20061017 4

Kaposi sarcoma-associated herpesvirus (KSHV) is etiologically linked to Kaposi sarcoma (KS), a tumor genetically akin to lymphatic endothelial cells (LECs). We obtained the immune transcriptional signature of KS and used KSHV-infected LECs (KLECs) as an in vitro model to determine the effects of KSHV on transcription and expression of genes involved in immunity. The antigen presentation, interferon (IFN) response, and cytokine transcriptomes of KLECs resemble those of KS. Transcription of genes ...[more]

PMID: 17047149

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