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Unknown,Transcriptomics,Genomics,Proteomics

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Illumina Microarray of MRC5 cell with or without KDM7A-DT overexpression

ABSTRACT: KDM7A Divergent Transcript (KDM7A-DT) is a stress-induced lncRNAs. In our previous studies, KDM7A-DT showed the most robust cellular phenotype alteration and a significant TP53-dependency upon oxidative and oncogenic stress induction. To investigate the functional roles of KDM7A-DT, we first performed overexpression experiments using fibroblasts. We found that MRC5 cells overexpressing KDM7A-DT escaped cell cycle proliferation and long-term survival ability and were associated with a distinct stress-related morphology (enlarged and flattened cells) compared to cells expressing just the vehicle control. To examine the effects of KDM7A-DT overexpression on the transcriptome, we performed a differential expression gene (DEG) analysis comparing a group of four independent biological replicates of MRC5 overexpressing KDM7A-DT to a group of samples from control cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Csaba Papp

PROVIDER: E-MTAB-11819 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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