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Comparison of transcriptome of SiHa-N (with pcDNA3 backbone vector) and SiHa-R (with RhoC over-expressing plasmid)

ABSTRACT: Since RhoC is known to be involved in various tumour phenotypes, a transcriptome analysis was carried out with RhoC over-expressing cells to identify the genes altered by RhoC over-expression.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Sweta Srivastava

PROVIDER: E-MTAB-12162 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer.

Pranatharthi Annapurna A Thomas Pavana P Udayashankar Avinash H AH Bhavani Chandra C Suresh Srinag Bangalore SB Krishna Sudhir S Thatte Jayashree J Srikantia Nirmala N Ross Cecil R CR Srivastava Sweta S Srivastava Sweta S

Journal of experimental & clinical cancer research : CR 20190905 1

<h4>Background</h4>Radioresistance remains a challenge to the successful treatment of various tumors. Intrinsic factors like alterations in signaling pathways regulate response to radiation. RhoC, which has been shown to modulate several tumor phenotypes has been investigated in this report for its role in radioresistance. In vitro and clinical sample-based studies have been performed to understand its contribution to radiation response in cervical cancer and this is the first report to establis ...[more]

PMID: 31488179

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