Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq mouse intestines from PN, Germ-free, SPF and Antibiotics-treated mice


ABSTRACT: We hypothesized that there were genes involved in the maintenance of intestinal tolerance to commensal bacteria. These genes should meet the following criteria: expressed in intestines, upregulated in the presence of commensal bacteria and downregulated in absence of microbes. To find these genes, we collected small intestines from postnatal mice that neither affected by the bacteria nor by the food, adult mice bred in germ-free or specific pathogen-free conditions, and adult SPF mice treated with antibiotics. We therefore performed bulk RNA sequencing using these cells.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Pengyan Xia 

PROVIDER: E-MTAB-12215 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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