Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Bulk RNA sequencing of nine epidermal cell strains of different ages

ABSTRACT: We wanted to investigate the transcriptome intrinsic changes of young and old adult skin keratinocytes.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Vassia Salameti 

PROVIDER: E-MTAB-12897 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Methylation levels in keratinocyte basal cells reflect donor age and associate with altered cellular proliferation pathways.

Salameti Vasiliki V   Tomas Ines M IM   Gunn David A DA  

Epigenomics 20250706 11

<h4>Aims</h4>To determine if epigenomic and mRNA associations with donor age are present in basal keratinocytes <i>in vitro</i>.<h4>Methods</h4>Whole-genome methylation (EPIC array), RNAseq analysis, and in vitro cell growth assessments were performed on cultured keratinocytes (<i>n</i> = 9, 22-68 years), enriched for cells expressing the stem cell protein markers ITGB1 and EpCAM.<h4>Results</h4>Donor age associated with 1,244 differentially methylated positions (DMPs) (<i>p</i> < 0.01, >20% del  ...[more]

Similar Datasets

Transcriptomics Bulk RNA-Seq of lung Type 2 Innate Lymphoid cells (ILC2) in response to papain
2025-12-10 | E-MTAB-15989 | biostudies-arrayexpress
Transcriptomics Bulk RNA-Seq of lung Type 2 Innate Lymphoid cells (ILC2) in response to Alternaria alternata
2025-12-10 | E-MTAB-15967 | biostudies-arrayexpress
Transcriptomics RNA Seq Data of adult Drosophila melanogaster heads with Mushroombody-specific knockdown of Atg5 in comparison to wildtype controls
2026-06-30 | E-MTAB-17037 | biostudies-arrayexpress
Genomics Bulk RNA sequencing of nine epidermal cell strains of different ages
| PRJEB61816 | ENA
Transcriptomics Macrophages Solvent, AA, LPS, AA+LPS
2021-12-31 | E-MTAB-10866 | biostudies-arrayexpress
Transcriptomics RNA-seq of monocyte derived macrophages exposed to arachidonic acid, interferon beta, or interferon gamma
2021-12-31 | E-MTAB-10867 | biostudies-arrayexpress
Transcriptomics RNA-seq of Human monocyte derived macrophages exposed to arachidonic acid, IL6 or both
2021-12-31 | E-MTAB-10868 | biostudies-arrayexpress
Transcriptomics EPIC microarray of 8 keratinocyte cell strains of young and old adults
2023-07-03 | E-MTAB-12878 | biostudies-arrayexpress
Transcriptomics Drosophila midgut RNAseq timecourse, high yeast vs high sugar diets
2021-10-01 | E-MTAB-10812 | biostudies-arrayexpress
Transcriptomics RNAseq of HeLa and U2OS cells treated with either Nutlin, Darpin C10 targeting p53 or a control DARPin
2025-09-05 | E-MTAB-13602 | biostudies-arrayexpress