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Bic v wt expression array1

ABSTRACT: global gene expression in caecal patch and colon of miR-155 deficient and C57BL/6 mice following infection with Citrobacter rodentium

ORGANISM(S): Mus musculus

SUBMITTER: Simon Clare

PROVIDER: E-MTAB-1301 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice.

Clare Simon S John Victoria V Walker Alan W AW Hill Jennifer L JL Abreu-Goodger Cei C Hale Christine C Goulding David D Lawley Trevor D TD Mastroeni Pietro P Frankel Gadi G Enright Anton J AJ Vigorito Elena E Dougan Gordon G

Infection and immunity 20121221 3

MicroRNAs (miRNAs) are small noncoding molecules that control gene expression posttranscriptionally, with microRNA-155 (miR-155) one of the first to be implicated in immune regulation. Here, we show that miR-155-deficient mice are less able to eradicate a mucosal Citrobacter rodentium infection than wild-type C57BL/6 mice. miR-155-deficient mice exhibited prolonged colonization associated with a higher C. rodentium burden in gastrointestinal tissue and spread into systemic tissues. Germinal cent ...[more]

PMID: 23264052

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