Unknown,Transcriptomics,Genomics,Proteomics

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Flagellin_Illumina_Microarray

ABSTRACT: the aim of the study was to assess the role of flagellin in the interaction bwetween Salmonella Typhi and host cells. A macrophage-like cell line (THP1) and an epithelial cell line (Hep2) were infected with S. Typhi expressing one of three flagellin variants: Hd, Hj or Hz66. A non-flagellated mutant (DfliC) and a non-invasive mutant (DinvA) were used as controls

ORGANISM(S): Homo Sapiens

SUBMITTER: Fernanda Schreiber 

PROVIDER: E-MTAB-2395 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions.

Schreiber Fernanda F   Kay Sally S   Frankel Gad G   Clare Simon S   Goulding David D   van de Vosse Esther E   van Dissel Jaap T JT   Strugnell Richard R   Thwaites Guy G   Kingsley Robert A RA   Dougan Gordon G   Baker Stephen S  

Scientific reports 20150122

Salmonella Typhi, the causative agent of typhoid fever, is a monophyletic, human-restricted bacterium that exhibits limited phenotypic variation. S. Typhi from Indonesia are a notable exception, with circulating strains expressing diverse flagella antigens including Hj, Hd and Hz66. Hypothesizing that S. Typhi flagella plays a key role during infection, we constructed an S. Typhi fliC mutant and otherwise isogenic S. Typhi strains expressing the Hj, Hd, Hz66 flagella antigens. Phenotyping reveal  ...[more]

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