Unknown,Transcriptomics,Genomics,Proteomics

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Effects of upf1delta on RNA stability

ABSTRACT: The Upf1 protein is a major factor in nonsense-mediated decay. We used an in vivo labelling system (Cleary et al. 2005 Nat Biotechnol. 23, 232-7) to estimate the decay rates of upf1delta and wild type cells over-expressing the transcription factor Mei4.

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Juan Mata 

PROVIDER: E-MTAB-1324 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Functional characterization of Upf1 targets in Schizosaccharomyces pombe.

Matia-González Ana M AM   Hasan Ayesha A   Moe Gøril H GH   Mata Juan J   Rodríguez-Gabriel Miguel A MA  

RNA biology 20130416 6

Nonsense-mediated mRNA decay (NMD) is a highly conserved mechanism of mRNA degradation. NMD eliminates mRNAs containing premature termination codons (PTCs), preventing the production of truncated proteins with possible deleterious effects. However, there is mounting evidence that NMD factors, like Upf1, Upf2 and Upf3, participate in general regulation of gene expression, affecting the expression of genes lacking PTCs. We have used the fission yeast Schizosaccharomyces pombe to identify mRNAs dir  ...[more]

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