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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human monocyte-derived dendritic cells exposed to pathogenic and harmless fungi

ABSTRACT: To ditinguish different immune response and investigate the rule of proper recognition of fungi, a transcriptional analysis on moDCs exposed to a pathogenic and a harmless fungi was performed. Monocyte-derived dendritic cells were treated with Candida albicans, two different forms of Saccaromyces cerevisiae (whole organism and spore ascum) or untreated.

ORGANISM(S): Homo sapiens

SUBMITTER: Luca Beltrame

PROVIDER: E-MTAB-135 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential IL-17 production and mannan recognition contribute to fungal pathogenicity and commensalism.

Rizzetto Lisa L Kuka Mirela M De Filippo Carlotta C Cambi Alessandra A Netea Mihai G MG Beltrame Luca L Napolitani Giorgio G Torcia Maria Gabriella MG D'Oro Ugo U Cavalieri Duccio D

Journal of immunology (Baltimore, Md. : 1950) 20100312 8

In this study, we present evidence of differential Th17 responses in human monocyte-derived dendritic cells exposed to the pathogenic Candida albicans or the nonpathogenic Saccharomyces cerevisiae. We use different forms of the microorganisms, cells, hyphae, and spores, as a toolbox to dissect the role of surface mannan in the fungal immune response. In contrast to the S. cerevisiae yeast cell-induced Th1 response, dendritic cells stimulated with spores or C. albicans hyphae induce cellular resp ...[more]

PMID: 20228201

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