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Unknown,Transcriptomics,Genomics,Proteomics

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Stimulation of dendritic cells with cell wall components

ABSTRACT: In order to dissect the response from different fungal cell wall components, monocyte-derived dendritic cells obtained from healthy donors were collected and either left untreated, or treated for four hours with either mannan, zymosan, curdlan, whole yeast, or yeast spores. This experiment is related to E-MTAB-1213.

ORGANISM(S): Homo sapiens

SUBMITTER: Luca Beltrame

PROVIDER: E-MTAB-750 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The modular nature of dendritic cell responses to commensal and pathogenic fungi.

Rizzetto Lisa L Buschow Sonja I SI Beltrame Luca L Figdor Carl G CG Schierer Stephan S Schuler Gerold G Cavalieri Duccio D

PloS one 20120803 8

The type of adaptive immune response following host-fungi interaction is largely determined at the level of the antigen-presenting cells, and in particular by dendritic cells (DCs). The extent to which transcriptional regulatory events determine the decision making process in DCs is still an open question. By applying the highly structured DC-ATLAS pathways to analyze DC responses, we classified the various stimuli by revealing the modular nature of the different transcriptional programs governi ...[more]

PMID: 22879980

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