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Chip-seq of three TF in Rat liver

ABSTRACT: This study aims to study genome wide location of HNF4a, FoxA1 and CEBPA in wild type rat liver. Please note that all raw data files for this study were replaced with new versions on 12 March 2014 because the previous versions are corrupted. The corrupted files are associated with ENA run accessions ERR215698 to ERR215705 and should not be used. The correct files are associated with ENA run accessions ERR458085 to ERR458092.

ORGANISM(S): Rattus norvegicus

SUBMITTER: David Thybert

PROVIDER: E-MTAB-1415 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cooperativity and rapid evolution of cobound transcription factors in closely related mammals.

Stefflova Klara K Thybert David D Wilson Michael D MD Streeter Ian I Aleksic Jelena J Karagianni Panagiota P Brazma Alvis A Adams David J DJ Talianidis Iannis I Marioni John C JC Flicek Paul P Odom Duncan T DT

Cell 20130801 3

To mechanistically characterize the microevolutionary processes active in altering transcription factor (TF) binding among closely related mammals, we compared the genome-wide binding of three tissue-specific TFs that control liver gene expression in six rodents. Despite an overall fast turnover of TF binding locations between species, we identified thousands of TF regions of highly constrained TF binding intensity. Although individual mutations in bound sequence motifs can influence TF binding, ...[more]

PMID: 23911320

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