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Transcription Factor binding evolution in five mouse species

ABSTRACT: This study aims to compar transcription factor binding region between five mouse species.

INSTRUMENT(S): Illumina Genome Analyzer II

ORGANISM(S): Mus caroli

SUBMITTER: David Thybert

PROVIDER: E-MTAB-1414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cooperativity and rapid evolution of cobound transcription factors in closely related mammals.

Stefflova Klara K Thybert David D Wilson Michael D MD Streeter Ian I Aleksic Jelena J Karagianni Panagiota P Brazma Alvis A Adams David J DJ Talianidis Iannis I Marioni John C JC Flicek Paul P Odom Duncan T DT

Cell 20130801 3

To mechanistically characterize the microevolutionary processes active in altering transcription factor (TF) binding among closely related mammals, we compared the genome-wide binding of three tissue-specific TFs that control liver gene expression in six rodents. Despite an overall fast turnover of TF binding locations between species, we identified thousands of TF regions of highly constrained TF binding intensity. Although individual mutations in bound sequence motifs can influence TF binding, ...[more]

PMID: 23911320

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