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MRCA expression

ABSTRACT: We have created a global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma. We genotyped 408,273 SNPs and identified expression quantitative trait loci from measurements of 54,675 transcripts representing 20,599 genes in Epstein-Barr virusﾡﾧCtransformed lymphoblastoid cell lines. We executed genome-wide association scans for these traits.

ORGANISM(S): Homo sapiens

SUBMITTER: Liming Liang

PROVIDER: E-MTAB-1425 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines.

Liang Liming L Morar Nilesh N Dixon Anna L AL Lathrop G Mark GM Abecasis Goncalo R GR Moffatt Miriam F MF Cookson William O C WO

Genome research 20130123 4

Gene expression levels can be an important link DNA between variation and phenotypic manifestations. Our previous map of global gene expression, based on ~400K single nucleotide polymorphisms (SNPs) and 50K transcripts in 400 sib pairs from the MRCA family panel, has been widely used to interpret the results of genome-wide association studies (GWASs). Here, we more than double the size of our initial data set with expression data on 550 additional individuals from the MRCE family panel using the ...[more]

PMID: 23345460

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MRCE expression

Project description:We have created a global map of the effects of polymorphism on gene expression in 550 children from families recruited through a proband with atopic dermatitis. We genotyped >300,000 SNPs and identified expression quantitative trait loci from measurements of 16,487 probes representing 15,576 genes in Epstein-Barr virus¨Ctransformed lymphoblastoid cell lines. We executed genome-wide association scans for these traits.

2013-01-09 | E-MTAB-1428 | biostudies-arrayexpress

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2008-10-25 | E-GEOD-12452 | biostudies-arrayexpress

Genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma

Project description:Asthma is caused by a combination of poorly understood genetic and environmental factors. We found multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P < 10-12. In independent replication studies the 17q21 locus showed strong association with diagnosis of childhood asthma in 2,320 subjects from a cohort of German children (P = 0.0003) and in 3,301 subjects from the British 1958 Birth Cohort (P = 0.0005). We systematically evaluated the relationships between markers of the 17q21 locus and transcript levels of genes in EBV-transformed lymphoblastoid cell lines from children in the asthma family panel used in our association study. The SNPs associated with childhood asthma were consistently and strongly associated (P <10-22) in cis with transcript levels of ORMDL3, a member of a gene family that encode transmembrane proteins anchored in the endoplasmic reticulum. The results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma. Experiment Overall Design: Gene expression levels were evaluated in 404 children. We then evaluated the relationship between SNPs in the 17q21 region (which show association to asthma in the same children) with gene expression levels. See http://www.sph.umich.edu/csg/liang/asthma/

2007-11-09 | E-GEOD-8052 | biostudies-arrayexpress

Ganciclovir Plus Arginine Butyrate in Treating Patients With Cancer or Lymphoproliferative Disorders Associated With the Epstein Barr Virus

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AGS cells infected with Epstein Barr Virus

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2012-05-07 | E-GEOD-37753 | biostudies-arrayexpress

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