Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

31 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MRCE expression

ABSTRACT: We have created a global map of the effects of polymorphism on gene expression in 550 children from families recruited through a proband with atopic dermatitis. We genotyped >300,000 SNPs and identified expression quantitative trait loci from measurements of 16,487 probes representing 15,576 genes in Epstein-Barr virus¨Ctransformed lymphoblastoid cell lines. We executed genome-wide association scans for these traits.

ORGANISM(S): Homo sapiens

SUBMITTER: Liming Liang

PROVIDER: E-MTAB-1428 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

MRCA expression

Project description:We have created a global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma. We genotyped 408,273 SNPs and identified expression quantitative trait loci from measurements of 54,675 transcripts representing 20,599 genes in Epstein-Barr virusﾡﾧCtransformed lymphoblastoid cell lines. We executed genome-wide association scans for these traits.

2013-01-09 | E-MTAB-1425 | biostudies-arrayexpress

Genomic profiling of the overlap phenotype between psoriasis and atopic dermatitis

Project description:Clinical overlaps between psoriasis and atopic dermatitis are sometimes undiscernible, and there is no consensus whether to treat the overlap phenotype as psoriasis or atopic dermatitis. We enrolled patients diagnosed with either psoriasis or atopic dermatitis, and clinically re-stratified them into classic psoriasis, classic atopic dermatitis, and the overlap phenotype between psoriasis and atopic dermatitis. We compared gene expression profiles of lesional and nonlesional skin biopsy tissues between the three comparison groups. Global mRNA expression and T-cell subset cytokine expression in the skin of the overlap phenotype were consistent with the profiles of psoriasis and different from the profiles of atopic dermatitis. Unsupervised k-means clustering indicated that the best number of distinct clusters for the total population of the three comparison groups was two, and the two clusters of psoriasis and atopic dermatitis were differentiated by gene expression. Our study suggests that clinical overlap phenotype between psoriasis and atopic dermatitis has dominant molecular features of psoriasis, and genomic biomarkers can differentiate psoriasis and atopic dermatitis at molecular levels in patients with a spectrum of psoriasis and atopic dermatitis.

2023-06-24 | GSE182740 | GEO

Metagenome sequencing of feces of mouse treated D-galactose or not

Project description:D-galactose orally intake ameliorate DNCB-induced atopic dermatitis by modulating microbiota composition and quorum sensing. The increased abundance of bacteroidetes and decreased abundance of firmicutes was confirmed. By D-galactose treatment, Bacteroides population was increased and prevotella, ruminococcus was decreased which is related to atopic dermatitis.

2022-04-29 | E-MTAB-11632 | biostudies-arrayexpress

EGR1 increases the innervation density of epidermal sensory neurons via upregulation of ARTN in keratinocytes in atopic dermatitis

Project description:Atopic dermatitis (AD) is the chronic inflammatory skin disease accompanied with severe pruritus. To explore the roles of EGR1 in atopic dermatitis and the relationship between EGR1 and pruritus-scratching behavior, we used a atopic dermatitis-like mouse model driven by house dust mite (HDM) treatment in wild type and EGR1 KO mice, followed with RNA-sequencing analysis.

2024-01-15 | GSE214750 | GEO

Microarray transcriptome profiling of atopic dermatitis and psoriasis patients compared to healthy volunteers.

Project description:Characteization host-microbiome interactions in patients with allergic (model: atopic dermatitis) and autoimmune (model: psoriasis) diseases by integration of microarray transcriptome data with 16S microbial profiling. 6mm punch biopsies were collected from the skin of atopic dermatitis and psoriasis patients alongside healthy volunteers, and subjected to analysis using Affymetrix Human Gene ST 2.1 arrays.

2019-09-11 | E-MTAB-8149 | biostudies-arrayexpress

Staphylococcus aureus

Project description:Atopic Dermatitis

| PRJNA512846 | ENA

Optimizing single-cell transcriptomic discrimination of atopic dermatitis versus psoriasis vulgaris

Project description:Optimizing single-cell transcriptomic discrimination of atopic dermatitis versus psoriasis vulgaris

| EGAS00001007487 | EGA

641c8b17-6b33-41c8-a60a-ec83a72e5ede - samples

Project description:Optimizing single-cell transcriptomic discrimination of atopic dermatitis versus psoriasis vulgaris

| EGAD00001011104 | EGA

Genome-wide analysis of gene expression in the cervical spinal cord of a mouse model of atopic dermatitis

Project description:Genome-wide analysis of gene expression in the cervical spinal cord of atopic dermatitis model mice was performed. Results provide important information for understanding of molecular mechanisms of the symptoms of atopic dermatitis.

2015-07-17 | GSE70114 | GEO

The role of keratinocyte DDX5 in MC903-induced atopic dermatitis (AD) mice

Project description:To investigate whether DDX5 is involved in the development of atopic dermatitis, we performed gene expression profiling analysis using data obtained from RNA-seq of ear skins from Ddx5f/f and K14Ddx5f/f atopic dermatitis mice

2022-10-24 | GSE208669 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data