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The immediate early gene product EGR1 and Polycomb Group proteins interact in epigenetic programming during chondrogenesis

ABSTRACT: Chondrogenic differentiation was induced in ATDC5 cells in the absence (RNAi) or presence of EGR1 (Early Growth Response Protein 1); RNA samples were collected at t=0, 2, 4.5, 8,16, 24, 72 hrs.

ORGANISM(S): Mus musculus

SUBMITTER: Lars Eijssen

PROVIDER: E-MTAB-1464 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis.

Spaapen Frank F van den Akker Guus G H GG Caron Marjolein M J MM Prickaerts Peggy P Rofel Celine C Dahlmans Vivian E H VE Surtel Don A M DA Paulis Yvette Y Schweizer Finja F Welting Tim J M TJ Eijssen Lars M LM Voncken Jan Willem JW

PloS one 20130306 3

Initiation of and progression through chondrogenesis is driven by changes in the cellular microenvironment. At the onset of chondrogenesis, resting mesenchymal stem cells are mobilized in vivo and a complex, step-wise chondrogenic differentiation program is initiated. Differentiation requires coordinated transcriptomic reprogramming and increased progenitor proliferation; both processes require chromatin remodeling. The nature of early molecular responses that relay differentiation signals to ch ...[more]

PMID: 23483971

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