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Gata1_ter119_submission_papadopoulos

ABSTRACT: TODO

ORGANISM(S): Mus musculus

SUBMITTER: John Strouboulis

PROVIDER: E-MTAB-1504 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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GATA-1 genome-wide occupancy associates with distinct epigenetic profiles in mouse fetal liver erythropoiesis.

Papadopoulos Giorgio L GL Karkoulia Elena E Tsamardinos Ioannis I Porcher Catherine C Ragoussis Jiannis J Bungert Jörg J Strouboulis John J

Nucleic acids research 20130321 9

We report the genomic occupancy profiles of the key hematopoietic transcription factor GATA-1 in pro-erythroblasts and mature erythroid cells fractionated from day E12.5 mouse fetal liver cells. Integration of GATA-1 occupancy profiles with available genome-wide transcription factor and epigenetic profiles assayed in fetal liver cells enabled as to evaluate GATA-1 involvement in modulating local chromatin structure of target genes during erythroid differentiation. Our results suggest that GATA-1 ...[more]

PMID: 23519611

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